|
In enzymology, a thymidine phosphorylase () is an enzyme that catalyzes the chemical reaction :thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate. Thymidine phosphorylase is involved and used in the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme is involved in metabolic pathways: purine metabolism/pyrimidine metabolism, and bladder cancer. ==Structural studies== As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and . 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Thymidine phosphorylase」の詳細全文を読む スポンサード リンク
|